Southampton have won each of their last five league meetings with Sheffield United; in their Football League history, only against three sides have they won 6+ in a row: Hull (6 from 2011 to 2015), Crystal Palace twice (6 from 1955 to 1958, 7 from 2009 to 2015), and Newport County (8 from 1922 to 1955).
Sheffield United have lost both of their last two league visits to Southampton, but have never lost three in a row at the Saints before.
Southampton have only lost one of their last 26 home games on a Wednesday in the second tier (W18 D7), although that was to Sheffield United in December 2005 (0-1).
Sheffield United have won both of their last two league games on a Wednesday, last winning three in a row on this day of the week in March 2021 in the Premier League.
Sheffield United’s Chris Wilder has lost all five of his league games as a manager against Southampton, only facing Liverpool more in the Premier League/Football League without ever avoiding defeat (6).

Sky Bet Championship: Pre-match stat pack