Whether it's Leeds United's clash against Wigan Athletic in the Sky Bet Championship, the mouth-watering meeting between Ipswich Town and Peterborough United in Sky Bet League One or the promotion six-pointer between Swindon Town and Exeter City in Sky Bet League Two, one thing is for sure... this weekend is a big one.
Let's start our look ahead to the weekend with that game at Elland Road, one which could have implications at both ends of the table. Leeds went back to the top of the table in midweek after a thrilling comeback against Millwall, while Wigan picked up three much-needed points at home to Sheffield Wednesday in their battle to beat the drop. The Latics sprung a surprise to win this fixture last season, can they do so again?
Elsewhere, fresh from a huge win at Brentford, third-placed Nottingham Forest will be looking to capitalise on any slip-ups from the top two when they head to Birmingham City. Just above them are West Bromwich Albion, who will certainly be favourites to beat bottom side Luton Town on home soil, but suffered a disappointing defeat to Cardiff City on Tuesday night.
Finally, it's a trip back to Teesside for Tony Mowbray, who will be hoping his Blackburn Rovers side can continue their good run of league form when they take on Middlesbrough. Victory for the visitors could move them to within a point of the Play-Off places, depending on results elsewhere.
There are two games on Friday night, as Cardiff face Reading and Derby County take on Stoke City. Here's the full Saturday schedule...
We're all set for what is another huge weekend of action in Sky Bet League One, with several standout fixtures scheduled to take place. One of those comes from Portman Road, where Ipswich Town will be taking on fellow promotion hopefuls Peterborough United, who have had some big results of late and sit just two points below their next opponents.
Another highly anticipated clash will see a repeat of last season's Play-Off Semi-Final and EFL Trophy Final, as seventh-placed Portsmouth welcome Sunderland AFC to Fratton Park. Sunderland are among the form teams in the division and are right in the Play-Off mix, but a win for the home side here could see the sides switch places in the standings.
At the bottom, two of the bottom three sides are set to meet, as Tranmere Rovers travel to Bolton Wanderers. Tranmere remain six points from safety with two games in hand on the side above them, MK Dons, who face a tough test at home to Wycombe Wanderers.
There's no doubt about the big game of the weekend in Sky Bet League Two. It's first v second as Swindon Town host Exeter City, with just two points separating the sides ahead of kick-off. Occupying the third and final automatic promotion spot are Crewe Alexandra, who travel south to Walsall.
Colchester United's incredible unbeaten run now stands at 16 games; they sit fifth, just three points behind Crewe, and travel to a wounded Cambridge United side on Saturday. Cambridge suffered a 4-0 home defeat against Salford City in midweek, a result which ultimately saw them part company with manager Colin Calderwood.
Three of the bottom four sides have home matches this weekend and will be looking for three big points. This includes 24th-placed Stevenage, who will see their clash with 20th-placed Leyton Orient as an opportunity after back-to-back league defeats.