The action in the Sky Bet Championship gets started at the DW Stadium as Wigan Athletic welcome Preston North End for a 12.30pm kick-off.
The Latics have had an upturn in form of late and have won three out of their last five games in league action, seeing off high-flying Leeds United last weekend.
The Lilywhites sit just outside the Play-Off positions, three points behind Bristol City. Alex Neil’s side have been impressive this season and will be hoping that they can secure three points to put pressure on the teams above.
From Lancashire to Yorkshire as two rivals prepare to square up against one another.
Barnsley and Sheffield Wednesday’s games have always been tight affairs; the last fixture at Oakwell ending 1-1, with Ollie McBurnie and Adthe Nuhiu finding the net respectively on that occasion.
The late game in the Championship on Saturday comes from the City Ground as Leeds United travel to Nottingham Forest.
Like Leeds, Forest also lost last time out, with Birmingham City picking up the three points that day. Things could have been so different for Sabri Lamouchi’s men if Lewis Grabban would have put away his spot kick with his side leading 1-0.
One of the games in Sky Bet League One that promises to be a cracker is Sunderland AFC v Ipswich Town.
After a rocky start to the season things have somewhat improved for Phil Parkinson’s Black Cats, who now find themselves just two points outside the Play-Offs.
The Tractor Boys have been fighting for automatic promotion all season long and are in with a decent shout - a response is needed from Paul Lambert’s men though, after a 4-1 defeat to Peterborough United last weekend.
There are two games that could have significant impact at the both ends of the League One table, Coventry City v Bolton Wanderers and Tranmere Rovers v Portsmouth.
Coventry sit inside the Play-Off spots and, with a win over Bolton, the three points could see them leapfrog Wycombe Wanderers into second place, depending on results elsewhere.
A win for Tranmere Rovers meanwhile could see them climb closer to safety, whereas a Portsmouth win could strengthen or improve on their position in the Play-Off places.
League leaders Swindon Town have an attacking trio that would strike fear into any Sky Bet League Two defence. After re-joining from Bradford City and Rotherham United respectively, Eion Doyle and Jerry Yates welcomed Hallam Hope into the fold.
The front three and the rest of the Robins team travel to Carlisle United at the weekend, looking to make it two wins on the bounce after their 2-1 against Exeter City last time out.
Sticking with the Grecians, Matt Taylor’s side host bottom club Stevenage, who are in desperate need of a win as they battle with Morecambe for survival in League Two.
Exeter are level on points with Ryan Lowe’s Plymouth Argyle, who sit in the final automatic promotion spot on goal difference.
The Green Army are on the road at the weekend as they travel to Play-Off hopefuls Colchester United, one of this season’s surprise packages in league and cup action.
The Carabao Cup Quarter-Finalists were on the wrong end of 2-1 scoreline against Cambridge last weekend, while Plymouth were made it four wins out of five with a 1-0 over Newport County.