Twenty of the 24 teams in Sky Bet League One will be battling it out for three points this weekend, with the action getting under way at the Stadium of Light on Friday evening.
An unfamiliar foe for the Black Cats
Friday's clash between Sunderland and Accrington Stanley will be the first-ever meeting between the sides at the Stadium of Light. Stanley will be the 93rd different opponent that Sunderland have faced in English league competition, and a win for the Black Cats would lift them up to third in the table ahead of Saturday's fixtures. The visitors sit 16th, and haven't scored in six games, the longest run in the top four tiers of English football this season.
Hatters to set a new club record?
Luton Town's incredible form has been well documented in recent weeks and months, and the Hatters have a chance to make history this weekend. Should they avoid defeat at Fleetwood Town, they will have gone 20 league games without losing, having dropped just eight points out of a possible 57 ahead of kick-off. They won the reverse fixture 2-0 back in December, scoring with both of their shots on target.
Barnsley to keep up the heat?
Like Luton, Barnsley are flying, and will be hoping that results go their way on Saturday to consolidate their place in the automatic promotion spots. The Tykes sit second in the standings and face Wycombe Wanderers this weekend, looking to make it 12 league games unbeaten. Goals have been the theme of their recent matches; they've scored at least two goals in each of their last six League One games.
All to play for at the bottom
With Rochdale, Bristol Rovers and AFC Wimbledon all out of action, and just five points separating Plymouth Argyle in 15th and Bradford City in 23rd, this could be a huge weekend for the teams at the bottom. In fact, Plymouth will make the long trip to Valley Parade on Saturday after a recent upturn in form but aren't out of the woods yet - a win here could go a long way to easing the pressure.
High stakes at the Valley
As is the case at the bottom, things are tight at the top too, and Charlton Athletic's match against Blackpool could prove to be a big one for both sides. Charlton are currently fifth, but Blackpool are eighth and hoping to mount a Play-Off push of their own by recording a third straight league win over the Addicks for the first time since April 1972.
Around the grounds
Elsewhere this weekend, Portsmouth head to Southend United, looking to get back on track, with just three points separating themselves and the automatic promotion places. Another side in need of a positive result are Walsall, who have lost their last four - they make the short trip to Coventry City.
Gillingham sit inside the relegation zone, but victory over Scunthorpe United could lift them as high as 16th, depending on results elsewhere. Oxford United will too be looking to steer themselves away from trouble; they welcome Peterborough United to the Kassam Stadium.
Finally, 22nd-placed Shrewsbury Town host Burton Albion, hoping to end the longest current run without a win of any side in League One (eight games).