Two strikes from Kenneth Zohore set Cardiff City on their way to victory, as they defeated Leeds United 3-1 at the Cardiff City Stadium on Tuesday night.
Ipswich Town were also successful on home turf, running out 5-2 winners over Sunderland at Portman Road.
A share of the points looked to be on the cards at the KCOM Stadium, that was until Callum Robinson scored in the 88th minute to hand Preston North End a 2-1 triumph against Hull City.
Lee Johnson’s Bristol City side maintained their positive opening to the new campaign — recording a comfortable 2-0 victory at home to Bolton Wanderers.
Aston Villa turned in an impressive display to pick up all three points at the Pirelli Stadium, with Keinan Davis, Albert Adomah, Robert Snodgrass, and Josh Onomah all scoring in an emphatic 4-0 away win against Burton Albion.
Norwich City and Fulham picked up maximum points on the road too, as they got the better of Middlesbrough and Nottingham Forest respectively.
Two late George Saville strikes turned things around for Millwall, who prevailed 2-1 against Reading at the Den, while there were home draws for Barnsley and Brentford.
Twenty-four hours later, Sheffield United racked up another three points and Leon Clarke notched another two goals, with the Blades defeating Wolverhampton Wanderers 2-0 to move up to second.
Birmingham City ran out winners in Wednesday's other game, with Isaac Vassell getting his first for the club to sink Sheffield Wednesday, sending the Blues above Sunderland into 22nd.
Shrewsbury Town preserved their unbeaten start in Sky Bet League One, with Arthur Gnahoua scoring in injury time to earn the Shrews all three points in a 2-1 win over Doncaster Rovers at the Keepmoat Stadium.
A Nick Powell penalty, seven minutes from time, proved to be the difference as Wigan Athletic edged past Plymouth Argyle 1-0 at the DW Stadium to go second.
There was a five-goal thriller at Boundary Park, where Oldham Athletic eventually prevailed, narrowly coming out on top against Peterborough United.
Both Blackpool and Scunthorpe United had to settle for draws in their fixtures with Rochdale and Gillingham respectively, as did Charlton Athletic, who drew 2-2 at Walsall.
Blackburn Rovers and Fleetwood Town did pick up wins though, with Rovers defeating Rotherham United 2-0 at Ewood Park, and Uwe Rosler’s Cod Army scoring three second-half goals to triumph at Bradford City.
Also scoring three were Bury and Portsmouth, who additionally kept clean sheets in their home outings against Oxford United and Bristol Rovers respectively.
Jason Demetriou scored the only goal of the game at Roots Hall, as Southend United made it back-to-back wins in the league.
Elsewhere, there was nothing to choose between Milton Keynes Dons and Northampton, who played out a goalless draw at Stadium MK.
Notts County won the top of the table clash with Exeter City, with substitute Jorge Grant scoring twice in a 3-0 away win at St James Park.
Another man to find the net on two occasions was Billy Kee, as Accrington Stanley defeated Port Vale 2-1 at Vale Park.
Coventry were 2-1 winners at Swindon Town and they won the game in fine style too, with Duckens Nazon scoring a superb second for the Sky Blues 14 minutes from time.
There were also victories on the road for Stevenage and Yeovil Town, while Luton Town earned a point away at Morecambe.
Late drama presented itself at Adams Park, where Crewe Alexandra looked to be heading for all three points against Wycombe Wanderers. However, despite there only being minutes left on the clock, the hosts scored twice, firstly through Michael Harriman and then Nathan Tyson, to take all three points in a 3-2 triumph.
Wins too came the way of both Cambridge United and Cheltenham Town, who each recorded 3-0 successes, over Forest Green Rovers and Mansfield Town respectively.
Also picking up maximum points were Lincoln City, with Danny Cowley’s men seeing off Barnet 2-1 at Sincil Bank.
At Blundell Park, Grimsby Town substitute Sam Jones equalised from the penalty spot to earn a share of the spoils in a 2-2 draw with Colchester United.