Sky Bet League One leaders Scunthorpe United travel to Peterborough United in a full midweek schedule on Matchday 19.The Iron have won four games on the spin, but Posh have ran out victors in their last three and sit fifth.
Second-placed Sheffield United are 13 unbeaten, and face a Bury side who have lost eight consecutive EFL fixtures.
There's a new London derby in the EFL, with Millwall hosting AFC Wimbledon. The Lions have won both previous cup meetings at The Den, but this is the first league clash between the pair.
Elsewhere, Bolton and Bradford - third and fourth respectively - host Coventry and Northampton, while Fleetwood bid to extend their scoring streak when Shrewsbury come to Highbury.
Sky Bet League One: Matchday 19 fixtures (7.45pm kick-off unless stated)
Tuesday 22nd November 2016
Bolton Wanderers v Coventry City (8pm)
Bradford City v Northampton Town
Bristol Rovers v Charlton Athletic
Fleetwood Town v Shrewsbury Town
Millwall v AFC Wimbledon
Milton Keynes Dons v Chesterfield
Oxford United v Gillingham
Peterborough United v Scunthorpe United
Port Vale v Oldham Athletic
Rochdale v Walsall
Sheffield United v Bury
Southend United v Swindon Town
Referees: Click here to see the match officials on duty
1. Bolton and Coventry go head-to-head for the first time since a top-flight fixture in 1998, when the Sky Blues romped to a 5-1 away victory. The pair have never met in the third tier of English football.
2. Bradford are unbeaten in their last eight encounters against Northampton. Five of those came in the 2012/13 season when the Bantams recorded a league double, advanced in the FA Cup via a replay, and won the Sky Bet League Two Play-Off Final against the Cobblers at Wembley.
3. Matches between Oxford and Gillingham are notoriously close affairs, with the last 11 either finishing all square or settled by a one-goal margin.
4. Sheffield United and Bury meet for the 100th time. The Shakers won the maiden meeting in 1895, and did the double over the Blades last term, but it's United who dominate the head-to-head with 46 wins to 29.
5. Swindon have won seven of the last eight against Southend, including five straight successes. The other was a 2-2 draw at Roots Hall in 2010.
From the dugout
"Left-back's on!"— EFL (@EFL) November 21, 2016
"Oh no, wait, that's a steward..."
📰 A plaque commemorating the @EFL's first ever goal will be unveiled in a special ceremony tomorrow evening » https://t.co/ZJaU973r94#BWFCpic.twitter.com/UODQMXckhj— Bolton Wanderers FC (@OfficialBWFC) November 21, 2016
UPDATE: An update on the condition of the Memorial Stadium pitch ahead of tonight's game with @CAFCofficial! https://t.co/Z8j6uTNpXEpic.twitter.com/GQEcaPbdHM— Bristol Rovers (@Official_BRFC) November 22, 2016
MATCH PREVIEW | Michael Timlin wary of Swindon threat 🔵⚽️ - https://t.co/L6VI2NFSDLpic.twitter.com/9rcFjw3xPg— Southend United (@SUFCRootsHall) November 22, 2016
WATCH 📽 | Here's a snippet of what @Jonathan_Obika had to say prior to tonight's game. Full interview with the striker up shortly #STFCpic.twitter.com/JDAseF1dIR— Swindon Town FC (@Official_STFC) November 22, 2016
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