Leyton Orient go to Northampton Town this weekend for the pair's first Football League meeting since April 2009.
And it's the first time the two have locked horns in Sky Bet League 2 since 2005/06 - a season which saw both sides promoted automatically from the division.The O's have had the better of Northampton in two recent Johnstone's Paint Trophy clashes, winning 2-0 at home last term and 3-0 at Sixfields in the 2012/13 season, but they approach this weekend after three winless games.
On the other hand, Northampton have won their last two outings, impressing in recent encounters with Oxford United and Morecambe, and boss Chris Wilder plans to 'go for it' against the division's leaders.
"The handbrake will be off and let's go for it,” Wilder told the club's official website.
“We’ve had two good performances and results and we want to make it three on the spin.
“I’m hoping and I’m expecting us to kick on but Leyton Orient will believe they can come here and win. Both teams will be going for the three points and there will be a lot of good attacking players on show."
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This fixture will be familiar to O's boss Ian Hendon, who had spells with both clubs during his playing career and was never on the losing side - winning four out of four while at Orient in the mid-90s, and going unbeaten against Orient with the Cobblers in 1999/2000.
Can Hendon continue that record in the 77th meeting between the pair? You can keep up-to-date with this, and all the division's other fixtures, by following our matchday Twitter feed - @SkyBetLeague2.