Shrewsbury Town headed back to the top of Sky Bet League 2 thanks to Jean-Louis Akpa Akpro's late winner at Newport County.Akpa Akpro came off the bench to score with 13 minutes left in a 1-0 win, which saw County's nine-match unbeaten run at home come to an end.
It sent the Shrews back to the top of the division as Wycombe Wanderers were held to a 0-0 draw at home by Portsmouth.
Joe Jacobson hit the bar the the Chairboys, who have now drawn six of their last eight league games and slip to third as Burton Albion beat Bury 1-0 thanks to Phil Edwards' goal.
Cambridge United head to Old Trafford on the back of a 3-2 defeat at Luton Town, but it could have been much worse.
The U's face Manchester United on Tuesday evening in a fourth-round replay in the FA Cup and their players may have had one eye on keeping fit for the Theatre of Dreams as the Hatters ran riot in the first half.
Andy Drury, Luke Wilkinson and Jonathan Smith all netted in the opening period to leave Richard Money's men reeling.
But Johnny Hunt and Robbie Simpson both scored in the second half to restore some pride in the second half.
Luton remain ahead of Southend United on goal difference after the Shrimpers beat York City 1-0 thanks to Shaquile Coulthirst's late penalty.
Jonathan Franks scored two and Scott Fenwick added the other in a 3-2 home win for bottom side Hartlepool United against Plymouth Argyle while Carlisle United climbed out of the relegation zone after coming from behind to beat Mansfield Town 2-1, who are now 23rd.
Dagenham & Redbridge also recorded a much-needed win, beating fellow strugglers Cheltenham Town 3-1 thanks to goals from Jamie Cureton, Ashley Hemmings and Alex Jakubiak, while Tranmere Rovers moved up four places to 17th with a 2-1 win at Exeter.
Marc Richards and Lawson D'Ath both scored twice as Northampton Town won 5-1 at Accrington Stanley, despite playing with 10 men for 52 minutes.
Ricky Holmes opened the scoring before Richards made it two from the spot, but Ryan Cresswell was sent off for denying Sean Maguire a goalscoring opportunity in the area.
Luke Joyce's resulting penalty was saved by Matt Duke but Piero Mingoia tucked in the rebound but two goals from D'Ath in the second half and another from Richards secured a fine win for the Cobblers.
Elsewhere, Oxford United were 2-0 winners at Stevenage, while Morecambe and AFC Wimbledon played out a 1-1 draw.