That is certainly the case for Rotherham United and Bolton Wanderers, who occupy two of the three places in the relegation zone.
They meet at the AESSEAL New York Stadium on Saturday, in the start of a period that could be pivotal in deciding their fate come May.
The stakes are high
Rotherham currently sit 22nd in the standings with 18 points, and could exit the drop zone with victory this weekend, should one of Milton Keynes Dons, Bristol City and, potentially, Huddersfield Town fall to defeats.
Bolton, regardless of the result, will remain in the bottom three, but can take huge step towards closing the gap to safety. The Trotters prop up the table in 24th, four points behind their weekend opponents and five adrift of 21st-placed MK Dons.
The form book
Despite their standing, Rotherham have actually picked up victory in three of their last six games. The latest was an impressive one too, as they beat fourth-placed Hull City 2-0 on home soil.
Prior to that, though, the Millers had lost three on the spin - to Wolves, Blackburn Rovers and Huddersfield - scoring just one goal in that time.
Bolton's record, on the other hand, doesn't make for pretty reading. Neil Lennon's side have collected just one victory all season, against Wolves more than three months ago. Since then, they've drawn eight and lost eight of their 16 matches.
This fixture brought goals, and plenty of them, in 2014/15, with 11 strikes hitting the back of the net in their two meetings, of which they won one each.
The home side has prevailed in each of the last four, and scored a minimum of two in the previous five, with the last away victory coming in February 1990.
Overall, the head-to-head figures stack in Rotherham's favour with 16 wins to Bolton's seven, while 13 draws have also taken place in their 36 clashes.
You can stay up to date with the goals as they hit the net in the Sky Bet Championship this weekend by following our divisional Twitter feed - @SkyBetChamp