Ricardo Moniz was the most recent departure, being relieved of his duties at Notts County earlier this week, leaving the Magpies, Dagenham & Redridge, Luton Town and Yeovil Town all looking for someone to turn their fortunes around.
Following the departure of Moniz, Chairman Ray Trew cited a lack of consistency as the reason for the managerial change. County sit 15th after a huge rebuilding effort in the summer.
“By this stage of the season I felt that we needed to be seeing more consistent performances, which would naturally translate into better results and we know all too well how much of a sand trap this division can be – the longer we linger and struggle, the more difficult it will be to get out," Trew told the club's official website
"My goal for this club is, and always has been, to improve and whilst I by no means want to keep chopping and changing managers, I refuse to let us stagnate and I feel that the time is right for a new approach to reignite our season and get us back on track to where we want and need to be."
Despite their disappointing position, the Magpies are only seven points off the final Play-Off spot, although they have played two games more than the current occupents, Carlisle United.
Another side who were setting their sights on promotion this term were Luton, who sit one place above Notts County and have shown signs of improvement under caretaker Andy Awford.
Awford stepped in to replace John Still and oversaw a dramatic 3-2 win away at Exeter City in his first game in charge.
A 2-0 defeat at home to in-form Wycombe Wanderers followed, but a goalless draw at high-flying Portsmouth - where Awford managed last term - was another fine result as the Hatters look to climb the League 2 ladder.
Dagenham & Redbridge
The Daggers parted ways with Wayne Burnett with the club currently involved in a relegation dogfight.
Success didn't come immediately after Burnett's departure - losing 3-0 to Cambridge United, but Darren Currie and Warren Hackett guided them to three points at Stevenage in Matchday 24.
Darren Way stepped in to replace Paul Sturrock at Huish Park, and has seen the Glovers improve despite still propping up the table as we enter the New Year.
Way, a club stalwart as a player, has been in charge throughout December and has only seen his side lose once in the League - a narrow 1-0 defeat at Plymouth Argyle.
Yeovil have drawn the rest - but holding strong opposition in Oxford United and Leyton Orient is no mean feat. Next up? A basement battle with York City.