Sky Bet League 2 leaders Wycombe Wanderers recovered from going behind after just two minutes to eventually beat 10-man Southend United 4-1 at Adams Park.Jack Payne put the visitors in front but a double from Matt McClure, plus goals from Paris Cowan-Hall and Joe Jacobson, turned the match around, with the dismissal of Jerome Binnom-Williams also giving Wanderers a boost.
Burton Albion powered up to second with a 4-0 thrashing of managerless Hartlepool United at the Pirelli Stadium thanks to a double strike by Alex MacDonald and further goals from Shane Cansdell-Sherriff and Stuart Beavon.
Luton Town had Steve McNulty sent off as they fell to a 3-0 defeat at Morecambe, with Kevin Ellison, Mark Hughes and Padraig Amond all hitting the target.
Shrewsbury Town were held to a goalless draw at Cambridge United, while Tranmere Rovers climbed out of the bottom two as Max Power scored the only goal of the game at Dagenham and Redbridge.
Carlisle United dropped into the relegation zone following a 2-0 loss at Exeter City, with Scot Bennett and Matt Grimes ensuring it would be a long and miserable journey home for the Cumbrians.
Newport County had Aaron O'Connor sent off in stoppage time, but he and Darren Jones had already got on the scoresheet in a 2-0 victory against Stevenage at Rodney Parade.
Plymouth Argyle survived a late rally to prevail 3-2 at Northampton Town, with Peter Hartley, Andy Kellett and Lewis Alessandra appearing to put the Pilgrims in control before Ivan Toney and Stewart Murdoch hit back late on.
Tyrone Barnett bagged a last-minute winner as Oxford United came from behind to edge out Bury 2-1, while Piero Mingoia's 78th-minute strike settled an entertaining encounter as Accrington Stanley prevailed 3-2 at Portsmouth.
Portsmouth had earlier fought back from conceding Rob Atkinson and John O'Sullivan strikes to level through Marcus Bean and Craig Westcarr.
There was another five-goal thriller at Bootham Crescent as AFC Wimbledon claimed a 3-2 win over York City thanks to goals from Jake Goodman, Sean Rigg and Matt Tubbs, with Diego De Girolamo and Stephane Zubar replying for the hosts.
Mansfield Town and Cheltenham Town shared the spoils in a 1-1 draw, with Zack Kotwica levelling late on for the Robins after Vadaine Oliver had broken the deadlock.