There's a Yorkshire versus Lancashire clash before two Midlands rivals square off a day later, and both will be live of Sky Sports.
Huddersfield Town and Blackpool meet at the John Smith's Stadium in Friday's 7:45pm start.
The Terriers come into the game sitting ninth on 12 points with just two losses in their eight league outings, but they have managed just one three-point haul in their last four Championship fixtures.
Meanwhile, Paul Ince's Tangerines are five places and five points better off, in fourth. After opening the campaign with five wins from six matches - form that saw them top the table - they have since taken just one point from the last six on offer.
There has been 74 encounters between the two sides in League action over the years and Huddersfield hold a one-game advantage. The Yorkshire side have won on 27 occasions - and took four points from last season's two matches - compared to Blackpool's 26, while 21 have finished level.
Then, at 12:15pm on Saturday, attention turns to the East Midlands where Nottingham Forest welcome near-neighbours Derby County.
Forest have lost just one league game this campaign but are another side who have struggled in recent weeks. Billy Davies' men drew 2-2 against Middlesbrough before sharing the spoils with Doncaster Rovers by the same scoreline last time out.
Nigel Clough's Rams also come into the game without a win in two matches having lost against Reading, which followed a stalemate with Bolton Wanderers. They will take confidence from their away record, however, having taken maximum points from three of their four games away from home.