Bolton Wanderers v Yeovil Town
Two of the bottom three teams meet at the Reebok Stadium where Bolton Wanderers welcome Yeovil Town.
The Trotters are one of only two teams still searching for a first Championship win, while Gary Johnson's Yeovil won on the opening day but have picked up just one point, scoring two goals, in the following seven outings.
The two sides have met just twice and Bolton have come out on top in both. They beat the Glovers 2-1 in the FA Cup back in 2001 before winning 2-0 three years later in the League Cup.
Bournemouth v Blackburn Rovers
Blackburn Rovers make the trip to the south coast where they will be hosted by Bournemouth.
Gary Bowyer's side have made an indifferent start to the term with two wins, three draws and three losses. Rovers were held to a goalless draw by Huddersfield Town in their most recent fixture and that extended their winless run to three games.
The Cherries have four wins to their name, with three of those coming on home soil. They drew 3-3 with Middlesbrough last time out.
Burnley v Charlton Athletic
Second in the table Burnley entertain a struggling Charlton Athletic side.
Sean Dyche's Clarets are just three points adrift of the submit and have registered two wins in their last two Championship matches, against Birmingham City and Leeds United.
The Addicks are without a win in three games - they sit 20th. They have lost all but one of their away games so far.
Sam Vokes scores the decisive goal in Burnley's 2-1 win over Leeds United last weekend
Huddersfield Town v Blackpool
There is a Yorkshire versus Lancashire clash in Friday's 7:45pm start as Huddersfield Town and Blackpool meet at the John Smith's Stadium in front of the Sky Sports cameras.
The Terriers come into the game sitting ninth on 12 points with just two losses in their eight league outings, but they have managed just one three-point haul in their last four Championship fixtures.
Paul Ince's Tangerines are five places and five points better off, in fourth. After opening the campaign with five wins from six matches - form that saw them top the table - they have since taken just one point from the last six on offer.
Ipswich Town v Brighton and Hove Albion
Brighton and Hove Albion travel to Suffolk to meet Ipswich Town.
The two sides are separated by just two points going into Saturday's fixture but Brighton hold the advantage in recent encounters against the Tractor Boys after losing just one of the last seven meetings.
Oscar Garcia's side will also take confidence from their current form. The Seagulls are undefeated in their last six, while Ipswich fell to their first loss in four last Sunday, losing 2-0 to Wigan Athletic.
Leicester City v Barnsley
Third meets 23rd at the King Power Stadium as Leicester City welcome Barnsley.
The Foxes have started their push for promotion in top form, picking up five wins in their opening eight league games, but they were held to a draw last time out by Blackpool.
Barnsley have registered just one victory so far and have conceded nine goals in their last three games, which have all resulted in defeats.
Millwall v Leeds United
Millwall will be aiming to continue their resurgence when Leeds United make the journey to The Den.
After starting the campaign with a winless run of six games, Steve Lomas' team have beaten Blackpool and Charlton in their most recent outings, while Leeds opened the term without a defeat in four before hitting their current form - one win in their last four league fixtures.
The Yorkshire outfit have the advantage in meetings between the clubs with 13 victories compared to Millwall's 11. The last three clashes have finished with a 1-0 scoreline.
Nottingham Forest v Derby County
Two East Midlands rivals square off in Saturday's 12:15pm kick-off when Nottingham Forest host near-neighbours Derby County.
Forest have lost just one league game this campaign but are another side who have struggled in recent weeks. Billy Davies' men drew 2-2 against Middlesbrough before sharing the spoils with Doncaster Rovers by the same scoreline last time out.
Nigel Clough's Rams also come into the game without a win in two matches having lost against Reading, after a stalemate with Bolton Wanderers. They will take confidence from their away record, however, having taken maximum points from three of their four games on the road.
Andy Reid found the net in the final 10 minutes of Nottingham Forest's game against Doncaster Rovers to rescue a point
Queens Park Rangers v Middlesbrough
Table-toppers Queens Park Rangers welcome Middlesbrough to Loftus Road.
QPR are the Championship's only unbeaten side and that has helped lift them to the league's summit. Their good form has been built on solid defensive displays - their 1-0 win over Yeovil Town extended their run without conceding a goal to 595 minutes.
Boro fought back from two goals down to take the lead in their most recent game but had to settle for a point after conceding a late own-goal against Bournemouth - their fifth stalemate of the season.
Reading v Birmingham City
Birmingham City travel to the Madejski Stadium to meet Reading.
The Blues picked up their second win of the campaign last weekend, beating Sheffield Wednesday 4-1 courtesy of a four-goal debut by Jesse Lingard, and knocked out Capital One Cup holders Swansea City in midweek Cup action.
Reading are also in good form as a Pavel Pogrebnyak double helped them overcome Derby 3-1 in their last outing to extend their unbeaten run to four matches.
Sheffield Wednesday v Doncaster Rovers
There is a South Yorkshire affair at Hillsborough on Saturday when Sheffield Wednesday take on Doncaster Rovers.
Neither side come into the game in good form as the Owls are still to register their first success of the campaign, while Paul Dickov's side have drawn two and lost one of their three games away from home.
The two clubs have met on 17 occasions with Wednesday coming out on top in 11 compared to Doncaster's four, but Rovers have won the past three encounters without conceding a goal.
Watford v Wigan Athletic
Two promotion-hopefuls clash as Watford entertain Wigan Athletic.
The fifth-placed Hornets have fallen to a defeat just once so far and are riding a two-game winning streak after overcoming Doncaster before trouncing Barnsley 5-1.
The Latics are four points further adrift but have played a game less. They got the better of Ipswich last weekend as goals from Ryan Shotton and Nick Powell helped Owen Coyle's men to a 2-0 win.