Birmingham City v Doncaster Rovers
Doncaster Rovers are 18th and travel to 19th-placed Birmingham City in search of their first victory against the Blues since 1954.
The two clubs have met eight times since Doncaster's most recent triumph, and all of those have been won by Birmingham.
Lee Clark's men have only collected eight points from their eight home matches but Rovers have only chalked up six points from their eight games on the road, winning just once.
Bolton Wanderers v Huddersfield Town
Bolton lost for the first time in eight last time out and now welcome Huddersfield Town to the Reebok Stadium for an 8pm kick-off.
Wanderers' bubble was burst at the Riverside against Middlesbrough, who triumphed 1-0, and it will be interesting to see how Dougie Freedman' 16th-placed team react against the Terriers, who they haven't lost to since 1999.
Huddersfield are 12th after back-to-back wins. They overcame Sean Dyche's high-flying Burnley 2-1 at the weekend.
Brighton and Hove Albion v Barnsley
Bottom club Barnsley begin life after David Flitcroft with a trip to Brighton and Hove Albion.
The Tykes suffered their 10th loss of the campaign to fellow strugglers Birmingham on Saturday and that sealed Flitcroft's exit, with the club six points from safety.
Oscar Garcia's Brighton drew at Bournemouth on Saturday to extend their unbeaten run to six matches. They trail the Play-Off places by three points.
Birmingham's Paul Caddis celebrates scoring the opening goal of the Blues' 3-0 win at Barnsley on Saturday
Burnley v Watford
Burnley were knocked off top spot at the weekend and host under-performing Watford on Tuesday night.
The Clarets lost 2-1 to Huddersfield Town - their fourth match without a win - and that allowed Leicester City to leap to the summit.
Watford are the Sky Bet Championship's worst performing side over the last six games with only two points collected. They lost 3-0 at home to Yeovil Town last time out.
Derby County v Middlesbrough
In-form Derby County entertain Aitor Karanka's Middlesbrough on Wednesday.
The Rams won 3-1 at Wigan on Sunday to secure their third successive three-pointer, and that was enough to move them in the Play-Offs.
Karanka picked up his first victory as Boro boss in his first home game at the weekend, against Bolton, giving his side something to build on, but they've only won once on the road so far.
Ipswich Town v Blackburn Rovers
Ipswich Town and Blackburn Rovers are locked on 23 points apiece in the Sky Bet Championship table and come together at Portman Road.
The Tractor Boys are the higher of the two with a goal difference of three, compared to Rovers' two, and have won two of their last three, most recently overcoming Charlton Athletic 1-0.
Blackburn were also 1-0 winners last time out, against Leeds, and haven't lost in the league to Ipswich for 20 years.
Leeds United v Wigan Athletic
Following that defeat to Blackburn, Leeds welcome managerless Wigan Athletic to Elland Road on Wednesday night.
The Latics parted company with Owen Coyle following Sunday's 3-1 defeat to Derby - a result that left them 14th in the table, six points adrift of the Play-Offs.
Graham Barrow and Sandy Stewart will be in charge of the team for the visit to eighth-placed Leeds, a team they've never lost to in league competition.
Millwall v Nottingham Forest
Lowly Millwall have one win in eight and take on Nottingham Forest, who have a solitary victory in six.
Neither side has been at their best in recent weeks and both were on the end of defeats last time out - the lowly Lions going down 3-0 at Leicester, and Forest, who are seventh, losing 3-2 at home to Reading.
The pair have already clashed this season, in the Capital One Cup, when Forest ran out 2-1 winners after extra-time.
Queens Park Rangers v Bournemouth
Queens Park Rangers and Bournemouth lock horns for the first time since 2004, at Loftus Road.
In their most recent encounter it was the Cherries who took all three points, courtesy of a Warren Feeney goal, but that's their only win against QPR since 1965.
Eddie Howe's men approach this game winless in six and with just one away victory so far. The Hoops are third but lost for the second time this season in their most recent match, at Doncaster.
Reading v Charlton Athletic
Charlton Athletic travel to Reading in the first league meeting between the two since 2009.
Both clubs have 12 wins apiece in the overall head-to-head record with the other 11 encounters ending level.
Reading are sixth and are unbeaten this season at the Madejski Stadium, winning four and drawing four. The Addicks are 20th and have lost three of their last four.
Sheffield Wednesday v Leicester City
The post-Dave Jones era at Sheffield Wednesday begins with a match at Hillsborough against leaders Leicester City.
The Owls lost their third game on the spin at the weekend and that was enough to see Jones axed, with the club sitting 23rd after winning just one of their opening 16 outings.
Leicester moved to the summit with their fifth victory in six on Saturday and they're the division's form team. They've won five of their eight matches on the road.
Yeovil Town v Blackpool
Yeovil Town and Blackpool come together for the first time since the 2007 League 1 Play-Off Final.
On that day in May, Blackpool were 2-0 victors with goals from Robbie Williams and Keigan Parker, and they're enjoying a productive season so far this time around, sitting fourth on 31 points.
After experiencing better fortunes in the League 1 Play-Offs last term, Yeovil are down in 22nd after 17 games but enjoyed a convincing 3-0 success at Watford on Saturday.
Blackpool celebrate Keigan Parker's goal in the 2007 League 1 Play-Off Final against Yeovil