Scunthorpe boss Brian Laws admitted his side's goalless draw at Bristol Rovers was "a missed opportunity".
Depleted Rovers, already missing 10 players through injury, saw their ranks depleted further when skipper and central defender Tom Parkes was stretchered off in the first half after being knocked unconscious in a tussle with striker Deon Burton.
The visitors had the better chances, twice hitting the woodwork, and were also thwarted by a goal-line clearance by Rovers defender Michael Smith and Laws thinks they should have made the most of the Pirates' problems.
"Given Bristol Rovers' injury problems, I think we'll look back and kick ourselves that we didn't take advantage of their situation," said Laws.
"There won't be many better opportunities to come here and get three points and we had the chances to do that. I couldn't fault our effort, only our finishing.
"But we have opened the season with three clean sheets and that, at least, has given us a base to build on because it's been a solid start.
"Credit to Bristol Rovers because their manager John Ward is having to play a lot of youngsters at the moment, but they dug in and made things very difficult for us."
There were few clear opportunities for the home side although David Clarkson went close from just outside the box.
Youngster Alefe Santos, who came on to replace Parkes, saw a good chance get away when he failed to control a pass from Ellis Harrison when well-placed inside the penalty area meaning Rovers had to settle for their first point.
Ward said: "We're off the mark with our first point from what was a very tight game.
"The situation we are in at the moment means everyone has to pull their weight.
"The kids are putting the shirt on and giving it a real good go - and I think our fans appreciate that
"Hopefully in a few weeks we can get some senior players back to help them out."